Characterization of Physical, Thermal and Spectral Properties of Biofield Treated 2, 6-Diaminopyridine

Diaminopyridine are important class of organic compounds, mostly used for synthesis of dyes, cosmetics, drugs and explosives. Recently, 2, 4-diaminopyridine was used as pharmacological agent for muscle relaxant used in anesthesia and it can increase the neuromuscular transmission in certain disease conditions. Additionally, 3, 4-diaminopyridine was used as a drug for the treatment of Lambert– Eaton syndrome (a rare autoimmune disorder characterized by muscle weakness) and also prescribed for multiple sclerosis [1]. Moreover, 4-aminopyridine a pyridine derivative was used for K-channel blocker in axonal membranes, and also to prolong the nerve action potential [2]. 2, 6Diaminopyridine (2, 6-DAP) is used for synthesis of hair dye and energetic compounds [3]. Besides, it is also used as intermediate for the synthesis of epoxy curing agent, polyamides, and preparation of analgesic phenazopyridine hydrochloride. Further, it was reported that amino pyridine and diaminopyridine are present in many biologically significant molecules such as folate, antifolate drugs, and cytosine derivatives [4]. However, it has been shown that 2, 6-DAP and related compounds have less water solubility and it does not cross the blood brain barrier [5], which limits its pharmaceutical applications. Hence, alternative strategies should be devised in order to improve the solubility and stability of the compounds. Mohammadi et al. used fast neutron and gamma irradiation to investigate the thermal, structural and colorant properties of 2, 6-DAP [6]. Recently biofield treatment has been reported to use as an effective alternative strategy for altering the physical and thermal properties of various metals and ceramics [7-10]. Hence, by considering the pharmaceutical significance of 2, 6-DAP, the present study was aimed to evaluate the influence of biofield treatment on physical, thermal and spectral properties of this compound.